If you are really hearing audible differences I'd say there was something wrong with your playback chain, not with the format.
Something wrong with my playback chain? Are you serious? :-)
I think Robin Whittle explains it well:
"Audio files contain a certain amount of information - "entropy" - so they cannot be compressed losslessly to any size smaller than that. So it is not realistic to expect an ever-increasing improvement in lossless compression algorithm performance. The performance can only approach more closely whatever the basic entropy of the file is. No-one quite knows what that entropy is of course . . . I think that would require understanding the datastream in a way which is exactly in tune with it's true nature. For instance a .jpg image of handwriting would appear to contain a lot of data, unless you could see and recognise the handwriting and record its characters in a suitably compressed format. The true nature of sound varies with its source, physical environment and recording method, and a lossless compression program cannot adapt itself entirely to the "true" nature of the sound in each piece of music. Therefore it is not surprising that different algorithms work best on different kinds of music."
Lossless? Not that I think so! :-)
Best wishes,
Alex Peychev