I owned the 17LS (the original, not the LS2 which uses the new capictors). The 16LS2 was a major step up in terms of clarity, bass response, and high end definition. What I heard, at least in IMHO, was a noticeable improvement in soundstaging (and the 17LS was already very good in this respect). I currently use Amperex 7308 green label in the pre-amp. I've rolled many tubes into the 17LS and the 16LS2 and this is the one I keep coming back to. The white label 7308s were a little too soft in the pre-amps but for some reason, at least in my system, work the best as the input tube in my C-J Premier 140 together with the green label 7308s in either pre-amp. I've tried Bugle Boys, Orange label 6DJ8s, HP labelled 6DJ8s in both, Telefunkens, Mullards, Siemens (including the pinched-waist varities when available of all of the above), ad nauseuem. I always come back to the combination noted. It's just a matter of the synergy with your system.
The 16LS2 is a very , very nice preamp.
Just my 2ยข.
Good luck.
Joe