Best universal remote control?

Harmony One has been the best for me, not available new, I believe, but many around.

I've been using a Universal Home Theater Master for about 15 years and it's great and has been bulletproof. One of the great things about it is the IR signal seems particularly strong so the remote is not senstive to direction and works almost no matter where you point it. I also like the hard buttons that are nicely laid out, so I rarely need to look at the remote to use the most common buttons -- drive by feel as it were. The downside is it's not the easiest remote to program, but once you've got the hang of it it's not bad and once you're done you're done.

I recommended Universal to a buddy of mine who likes stuff to "just work," and he bought one of their newer models and absolutely loves it. Not the smallest or prettiest remotes out there, but they work and work well. Hope this helps and best of luck.

A second vote for the Universal remotes. I got an MX-450 and absolutely love it. Setup can be a pain, but it's worth it. They perform exactly like they should. In my current setup anyone can grab the remote and learn to control everything within 1 minute.

I Highly Recommend Universal Remote brand.
I have the MX-350.
It can be setup to do ir or rf or both.
It is fairly easy to program and i think the button layout is perfect
http://www.universalremote.com/residential_user_interfaces.php