For the less than absolute anal set up specialist, and for only those using typical forward firing cone driver speakers, if you can get those speakers out a couple of feet from the plane of the TV screen, which should be no problem at all if you have already pulled your speakers out into the room far enuf to enhance the sense of depth of image and avoid unwanted bass enhancement, I wouldn't do anything. To check out the interference added by anything between your speakers, simply drape them with a heavy wool blanket.
Hope that helps a bit..
Hope that helps a bit..