Why am I experiencing listener's fatigue?

I'm with Goinbroke. Too much toe in. Try none and work in from there. Many speakers are designed and voiced for no toe in, and it is only used to ameliorate side wall issues when room treatments are not an option.

Have you tried to bi-wire the speakers with a different bi-wire speaker cable instead of running single with jumpers?
I have N803 and they are pretty bad when used with single run sp cable. I tried with different single run and bi-wire sp cable and with speakers on single run sp cable, I get tired really quick. I since have them bi-wired and no problems. I think B&Ws like to be bi-wired, regardless of the model. The jumpers they include with their speakers are nothing to write home about either. Also I have my speakers toed in so that tweete axis meets about 1 foot in front of me. I also listen near field, so that may be an option as well. FWIW. good luck

Yes, that is what i remember learning a long time ago but just forgot about. I was reading up on the bi wire sinlge strand debate and had decided from what i gleaned that bi wiring was the better way. I think i'll do that. Can you hear an audible difference or is it that you can just listen longer. It is very possible that the difference is inaudible and unfatiguing.Good tip. Your speakers point to a space one foot in front of you? Really. Hmmm. Interesting. I think i will bi wire sometime soon. I have gone to a doctor who now is sending me to specialist to check my ears. What a kaffufle! I hope i'm ok.

Hope you're OK man! It'd be a shame if the speakers did it to you... but I don't think so. Here is what I think about bi-wiring the B&Ws N803(I know you have the 805, but I think it applies). First thing that I notice when listenning with a single run is fatigue. What happpens with B&Ws, they just midrange like MOFOs when run with single sp. cable. It brings the midrange to a point where it is undigestable. My ears hurt. I immediately switched to bi-wire and it's a totally different sound now. Fatigue is gone and speakers just sound right. Much smoother throughout the whole spectrum. After you get checked out by your doc, and I really hope you're OK, is to go to the store where you usually buy your hi-end stuff, or at least where they know you, and get them to give you for home audition, some bi-wire sp cable. Make suer you get something good though, I'd say at least Monster M2.4s. B&Ws like a big fat speaker cable with as less of resistance as possible. I went to Stereo Exchange in NYC few months ago and listened to a system that consisted of McIntosh Integrated amp(I think it was like $6000 or something), Arcam FMJ CD33 player and B&W N805 speakers. Dude, I have the N803 and I did not know that the N805 can sound that frigging good!!! All was wired by Monster M1000 ic and Monster M2.4s bi-wire Speaker cable. I know the sales guy there since I bought a lot from them, they let me listen to whatever I want and as loud as I want to. I was in that room for almost 45 minutes, had no fatigue. But anyway, please let us know how this works out for you, most importantely your ears!!! Best of luck.

Oh...also, in your room it might be different with toe in. I said about a foot in front of me but I did check and they just cross in front of my face, not a foot, but may be 3-4 inches in front of me. But you know you have to experiment. And the funny thing is, when you move the speakers, the cables get moved as well, right? That is what you also have to consider - after you move the speakers, have them play for about 45 minutes to an hour before you evaluate them again. I noticed in my system that's the case - speaker cables need their time to come back to life again. May be that sounds crazy, but just what I observed in my system.