Speakers for Room Size

Should work, I see no issues, go for it!
IMO: should produce a fuller richer sound.
I have placed large speakers in rooms the size you describe with great results. 

When my audio system was in my living room (13x24), I had a pair of standmounts with sub woofer.  The larger floor standing models I was considering had a law WAF (wife acceptance factor), in that smallish living room.
When I moved down to a 24x26 "man cave", I did upgrade to a pair of floor standing units (with a pair of sub woofers).
One thing to think about (if you go with stand mounted speakers and a sub woofer or two), integrating sub woofers can be really problematic in some rooms.  Certainly that would not be as much of a factor with full range floor standing speakers.

I use Focal 936's in a room roughly that size. They sound great. My only suggestion would be liberal with wall distance. You're not going to need boundary reinforcement. Don't the PSB come with port bungs to tune their response down low? That might be a useful tool.