Forgive me but, that was unwise. You need to ALWAYS adjust bias in a fixed bias circuit if you change tubes, let alone tube types. 6550 and KT88s are NOT swappable without doing this.
Did the KT88 plates that blew the fuse turn cherry red by any chance before it did?
Did the KT88 plates that blew the fuse turn cherry red by any chance before it did?