Vandersteen 2wq with two way monitors

It depends. By design, the 2WQ subs cross over at about 80 hz, with a shallow slope, so your mini-moniter would need useful output about 1 octave below that.

I have tried it with a couple of speakers with limited bass like Spica TC50's and LS3/5a's. It never sounded right. The 2WQ works best with a more full range speaker.

In the Vandersteen website, it is suggested when the wall-mounted VSM(-3db @ 60Hz) is used for left and right main or surround speakers that it be mated with a 2WQ but with the crossover set 2 below the input impedance rather than the customary 1. So it can work with smaller speakers. However, the 2W was originally designed to be used with full range speakers with response -3db @ 40Hz.