Von Schweikert VR5SE / Aerial 20T V2 ?

Rilou, why do you want to change? What do you not like about you Andra 2's?

I would look elsewhere within your set-up and keep the Andra's they are amazing speakers.

The other two speakers you have mentioned are nice also.

I've heard both and they are both world class and have a lot of similarities. The 20t probably comes off as being a bit larger which could be a consideration if you're listening room is big. Ultimately the best choice would come down to synergism with your other components, and your personal preferences. I would strongly suggest listening to both in your set up. That's really the only way to tell.

I've heard both. VR5SE bass is outstanding. The lower midrange was a bit muddy (could be the amp or source). Highs were exagerated (had him turn down the back-firing tweeter but that only helped a little). This was the dealers personal pair in his home. Wasn't my type of sound reproduction. I urge you to listen to this speaker with your own ears before you buy.

20T. Great speaker top to bottom. The ribbon is directional, though (the dealer pointed it out and discussed it with me). Once out of the sweet spot the sound changes character. This is a great speaker, but the directionalness would bug me. I'd like to see that speaker without the ribbon.

Andra 2 is a great speaker. I'd look into your amplification before jumping into the VR5s or the Aerial.
Although between the Aerial and the VR5s, I'd choose the VR5s.

Fredrick21 makes great comments but I thought I would add to his concern over the directionalness (is that even a word?) of the 20t because I think it is overstated. In other words they'll take your breath away in the sweet spot which is and they'll sound great everywhere else. You know I heard that comment about the Vandersteen 5as I almost bought before the 20ts and then I realized I sit in that location anyway so who cares. Then I tried it and it was no big deal. That's not to say it won't bother you, but that's my experience.