Excellent suggestion on the room treatment An empty room with hard sides will slap echo like a bastard without treatment. Carpets on the floor, drapes on any windows etc. tame things considerably.
While one could probably be pretty happy with some small monitors in the middle of the room, I understand the urge to experience speakers that wouldn't have sounded very good in your previous smaller room.
Personally, I'd be looking to the second hand planar speakers and the suggestions of Martin Logan, Magnepan, SoundLab Apogee, are all good, and you can get used for decent dollars.
You can also look to conventional speakers that would have been a bit compromised by small rooms.
You may well be looking at an amplifier upgrade at some point, depending on what sort of load the speaker you choose presents.