If you think of them as MG1.6 'improved' I don't think you can go too far wrong.
As for amps / placement / setup, they are still Magnepan which means lots of space in back of 'em and sufficient quality power. Details count here.....
They will NOT be a wacky load, though I haven't seen any measurements, but if they follow Magnepan history, and MG1.6 practice, they will NOT have any dips in impedance and will also not have any phase angle issues. Any amp of good quality into 4ohms will work. Now, that being said, more power is indicated into large rooms and higher desired loudness. My MG1.6s with a 4 amp mid/tweet fuse make good use of ICE power 500ASP modules though I have not redlined it....ever. Those days are gone!