Charles your post is full of contradiction,
No need for mysticism
and
god given ears
Doesn't the idea of god invoke mysticism?
Then you go on to suggest that our ears have evolved. Weren't they given to us by god? Or maybe the ears that god gave us millions of years ago were less than perfect and have improved through evolution.
Sorry I couldn't help myself!
One day Larry had a room and a SS amp, speakers, a sources, cables, power conditoners and whatever else. Then a sales rep shows up in his room with a tube amp. The amps are swapped, and the "presence" is improved as perceived by Larry. On this basis, the room does not come into question, nor do any of the other components of the system.
The problem is not that "Science" can't measure the subtle differences, the problem as I see it is that there are so many factors at play that are interelated that it becomes extremely difficult to setup an experiment or model that can test the effects of each and every factor in relation to all the others given all the possible permutations and combinations.
In the end Charles I agree with you it comes down to using your ears (the god given ones or the evolved ones) to determine your personal preference through a process more a kin to art than pure science.