Eandylee, a differential amp is one where each of the signals is run through it's own amplification stage: Right hot, right neutral, left hot, left neutral. This requires a very careful matching of output devices (e.g., FET's). That's my understanding but I'm not an engineer so I may have misinterpreted something along the way. In any event, they are best served by XLR cables. My phono preamp will not accept an RCA and I had to go through some very interesting cabling mods to get everything to work right.