Distortion in amps;most/least annoying?

To broaden the response a bit, I find the distortions in electronics much more irritating than the distortions in transducers, i.e. speakers and phono cartridges. It seems that the distortions in electronics are less consonant with the struture of the music. That said, solid state type distortions that start to pile up in the upper midrange/lower treble drive me nuts. As hunter/gatherers this may be the range that we are most sensitive to.

Right now I'm looking to add sone second order distortion to the upper mids. Might bias the drivers hotter. Intrestingly my speakers (Omega) are wired with bigger gage on the positive than the negitave. I wonder?

Any kind of coloration. Enhanced mids, rolled-off highs....
I don't need the the amps to interpret, filter or exaggerate , just amplify as honestly and competently as possible. It's not always pretty and it's easy to be tricked by a convincing liar.