From my experience and reports I read from others, it does seem that use of negative feedback typically results in a more laid back presentation than otherwise. That would seem to infer a different tonality between the two in general. So avoiding that is probably a good move in the interest of achieving a more "direct" sound than otherwise.
I owned one near zero feedback amp in recent years as an experiment and yes it tended to be more direct and forward than most others I have owned.
I owned one near zero feedback amp in recent years as an experiment and yes it tended to be more direct and forward than most others I have owned.

