Number of tubes would not be a problem for me unless each cost $1k and lasted only for a year. It's a bit more difficult to do amp first approach than speakers first approach. But with Atma-Sphere and LAMM I would still do exactly that.We warrant the tubes in our gear for a year and they are relatively inexpensive.
The only real worry is as said, clipping. Its when a driver is starved for power predominately. Usually it’s a tweeter. Ordinarily clipping occurs when running the spkrs at higher levels and the power a driver asks for can’t be provided appropriately or comes intermittedly. That’s when actual . damage to the loudspeaker can take place. It happened in a pr I had bought preowned. His INT did not have the power to satisfy those speaker’s demands and one of the four blew out. Quit working. The factory fixed it eventually. Once I paid for shipping and so forth.The mechanism for this is when the amplifier clips, the distortion generated is high enough in frequency that the crossover allows it through to the tweeter(s), which usually only handle maybe 2 watts or so. With solid state amps in particular, overloading the amp is a good way to toast the tweeters.
This is considerably more rare with tube amps because they generate less higher ordered harmonics when overloaded (which is usually caused by bass notes) but still can happen.
If you see tweeters blown and nothing else, its a sure sign that the speaker was exposed to an amplifier that was clipping. Most manufacturers would not consider that as a warranty claim as it is clearly abuse of the speaker.