I use a PS Audio P600 regenerator for my digital gear. ( Fruman REF20i for the other, amp to wall)I would say depends on what you are wanting to be 'better'.Generally conditioning will improve high frequency clarity and quality most, less grain and hash in HF sound. Tighten bass up. (less tubby) downside may seem like less bass output.
It may make the midrange seem a little less full, again tightening up.So, it you want more clarity, tighter sound. less grain.
It may make the midrange seem a little less full, again tightening up.So, it you want more clarity, tighter sound. less grain.

