I'm taking a poll...

assuming you have on-the-fly VTA, why not adjust it? It makes quite a bit of difference when the VTA is dialed in. I mark the setting on the plastic sleeve of the LP and can quickly reset for each LP.

I adjust VTA by listening to width and depth of the soundstage, and also to clean definition, but I do not adjust VTA as a tone control. Although my VPI tonearm is VERY easy to adjust on the fly...I just leave it alone once I get it to my satisfaction

I would have to say B, as on my VPI I adjust for what is TO ME the proper balance between treble and bass. I knock no one for adjusting VTA (and VTF) for different thicknesses of LP's nor for doing same for every LP. I'm just not that anal. Also, the amount of adjusting I do is inversely proportional to the amount of zinfandel or single malt I have imbibed.--Mrmitch

B. But I do A so I can live an easy life.

I go for A, life is too short to adjust VTA with each record, particularly if VTA is not adjustable on the fly. The extra factor to consider is the cartridge. I think there is no doubt VTA affects the sound, in general front down accentuates treble, back down the base. I know it is'nt as simple as that. For my last Koetsu Rosewood signature, it sounded better front down slightly, with my current Zyx Airy 3, dead level.
I do'nt think one should ignore the potential for "tuning " the sound to your preference.