Proper Cable Placement.

Having discovered recently the improvements of moving all powercords away from interconnects , lets move on to proper placement of interconnects . Lets use interconnects going from pre amp to amp as an example. Is it best to keep the left and right interconnect as far away from each other as possible? Is it the reverse , should they be gently twisted around each other? What are your thoughts on this and general interconnect placement to ensure minimal interference and maximum performance? Appreciate your thoughts........