Will a quality USB cable make a difference....

I am currently using an Audio Research DAC8 connected to an usb music server and I can tell you there is a big difference in sound quality of usb cables. I have been using an Audioquest carbon usb cable. It is a very good usb cable and I would recommend it. I have just purchased an Audioquest Diamond usb cable and there is a big difference in my system. The Diamond usb cable is so much better ,it is across the board better than the carbon usb cable. The top end air, the transparently and better defined bass are easily distinguished differences. Don’t let anybody kid you there is no difference among usb cables. The difference to me is just like all the rest of the cables. They all sound different.

Does it matter where the USB is used?

In my case, I am using a Squeezebox Touch with its digital to my Dac.
But, I am using a USB cable from my computer to my 1 TB External hardrive where my music is stored.
Would a higher end USB cable be useful in that application ?

I only know about running a usb cable from the computer main board to the DAC8. My music server only has an internal 2 TB disk drive SATA II connected and no external usb disk drives. So I can't help you Ozzy. If you figure it out report back as I would like to know also.

"It takes adecades of dedecation". We are not learning to play the music on an instrument or be the next beethoven, just through our audio system. Some times it takes a long time to afford, but that is the beauty of a computer based music system, it lowers the entry costs. Now instead of spending 10's of thousands of $ on a front end you can do it for a few $1000, which leaves more for the speaker and amp side of things. You do not need to be a sound engineer or a wizz kid. Just a true enthusiast with the desire. Oh,and the money but with a lot less needed. Speakers, line stage, amp, dac and a computer. How much easier can it be. Don't waist your $ on expensive digital cables no real impact for the $(moving 1's and 0's). Spend it on the body of the system. MY OPINION!

correction; decades of dedication