kt88 vs. 6550 noobie question

No. Not just plug and play. Bias will have to be adjusted to accomodate 6550's unless your amp has an auto bias curcuit which will compensate for the difference.

But, that is not a big deal because even new/different KT88's, when you replace yours, will need to be rebiased as well (unless your manufacturer has advised you to the contrary in its manual). They all have different bias points.

Newbee, hit's the note as you can change out the KT88 with the 6550, but you got to re-adjust the bias. The KT88 are probably better sounding than the 6550, but unfortunately they are a more fragile tube. If you can get a quartet of KT88s past 30 days you're probably all right, but unfortunatley, there does seem to be a high failure rate with the KT88 tube. I'm currently using the current issue of the Tung-Sol 6550, which seems to be good tubes, but true be told the Sovtek 6550 is the standard for realiability.

I have been using KT88s without any failures for some years now. That doesn't mean they are not more fragile than 6550s.
May mean I'm just lucky. The new Genalex Gold Lions KT88s are the best sounding to my ears in my system.

Any time power tubes are changed in an amp(providing it is not auto-biasing, as mentioned): The amp/tubes must be re-biased, then re-checked in a couple days. Give the amp(s) at least 30 minutes of warm up before biasing(to allow the voltages to stabilize). If you are concerned about reliability of a chosen tube: Contact Kevin at Upscale. He'll give you the straight scoop, and his testing/screening/burn-in procedures are second to none. (http://www.upscaleaudio.com/view_category.asp?cat=85) KT-88s (or any other tube) may, or may not, be more likely to fail based on where and by whom they were manufactured, how they were handled in shipment, how they are biased, and if the gear they are used in is especially hard on tubes. Lots of variables. You may be interested in these if your taste is for accuracy rather than tubiness: (http://www.euroaudioteam.com/pdfs/eat_tubes_september_2004.pdf)