Well, as this topic applies to my system in my admittedly limited experience running a few stereo amps and a few sets of monoblocks, when comparing the sonic results given a choice between 30 foot balanced interconnects and 6 foot speaker cables, or 30 foot speaker cables and 3 foot interconnects (either balanced or single ended), I have heard clear improvements using the former, which is the monoblock configuration.
Now, I did not compare amplifiers in both stereo and monoblock versions from the same manufacturer, nor did I compare the different cable lengths of the same model cabling. The expense to do so was prohibitive.
Nor did I try uber-expensive cabling of either type for the 30 foot run. Again, this would have been cost prohibitive.
I imagine, given no ceiling on cost, one could likely run 30 foot speaker cabling from an outstanding stereo amplifier with no discernible sonic penalty, but this was not the recommendation of the speaker manufacturer at the time of my decision to go with monoblocks. In fact, the manufacturer was adamant about avoiding long speaker cable runs.
With the constraints of installation and cost, monoblocks became the appropriate choice for my system.