Brad, if the manufacturer says it compatible, then go for it! 5V4Gs are cheap. 5Y3s cheaper yet. You might also want to consider the Mullard 5AR4 which is the best example of a 5AR4.
The reason that I like the instrumentation or ruggedized grade of the 12AU7 is that they tend to be much less microphonic, which seems to be a great problem in this tube type. Many of the ruggedized versions are built to be much more stout for use in hostile environments or left on 24/7, the 5814 is another good example that is a direct sub for 12AU7. There are some more such as 6189, which I have not had good luck with, as well as 7730, 7318, and 6067, which I have no experience with. Sometimes these instrumentation grade 12AU7s sell for peanuts, so it is fun to try things out, as you will be doing with the 5V4. Good luck, and most of all, enjoy yourself.
The reason that I like the instrumentation or ruggedized grade of the 12AU7 is that they tend to be much less microphonic, which seems to be a great problem in this tube type. Many of the ruggedized versions are built to be much more stout for use in hostile environments or left on 24/7, the 5814 is another good example that is a direct sub for 12AU7. There are some more such as 6189, which I have not had good luck with, as well as 7730, 7318, and 6067, which I have no experience with. Sometimes these instrumentation grade 12AU7s sell for peanuts, so it is fun to try things out, as you will be doing with the 5V4. Good luck, and most of all, enjoy yourself.

