Two systems in the same room

Well... I've done this for a couple of years now and I don't feel I've had any big down sides. I just throw a blanket over the speakers I'm not using and that seems to solve the problem. At various points I've had just the Maggie's in the room and I didn't notice any difference. Although I do have the room optimized to work best for the Maggie’s. And as for the Meadowlarks I listen in the near field so room interactions have not been a big issue. I suppose at some point I will lose the second system and upgrade my electronics but for right now it works. Just my 2 cents...

We did this for a while, and it worked great. SET amps with horns for one system, and a hybrid integrated with box speakers for the second system. Both ran from a single source that had two sets of outputs. There are very few systems IMO that can effectively cover the entire musical spectrum while at the same time remaining true to the sound you prefer. Most are compromises, one way or another. Maybe a system sounds full enough for rock, but is not quite intimate enough for jazz. Maybe it sounds seductive on chamber orchestra, but gets compressed when the music becomes more complex. If two systems allows you to eliminate the compromise, why not? On the other hand, if you opt for a pair of speakers that can cover it all to your liking, then just swap amps depending upon your mood. So...what's yer budget???

I have 6 sets of speakers in one large room, 2 separate systems: Analog LP and a home theatre.. I cannot distinguish any downside to the sound of the active playing loudspeakers being interacted upon by the inactive ones sitting there.. What interactions should I be hearing?

I also have a 7.1 Canton HT setup and a pair of B&W 805s in the same room. no problems.
The Cantons are all on/next to the walls and the B&W out into the room a few feet.

Thanks everybody. I currently have an old setup of Krell 400xi integrated SS amp and Sonus Faber Cremona Auditors that don't do it really well for rock. I was thinking of going in to purchase of some stronger speakers and some tube gear (since I never had any, I would like to try) and my budget is around 10000$, and then try to mesh the Cremonas to tubes and Krell to the new speakers. I would by it second hand, since that way I think I can get more for the money. What do you think.