That is broad question so I will answer it this way. As a general matter I have found MFSL disks (assume you mean LPs not CDs) much better sounding than the average retail pressings. That said many titles that were issued by MFSL have since been reissued as 180, and 200 gm reissues or can be found either as Japanese or European imports. There are many previous threads that discuss the quality of various reissues including comparing them to the MFSL pressings.
