Obviously depends on the size of the speakers and room. I think there is a critical distance, for any pair of these components that cannot be shorten. Then you may widen it as long as you feel that the sound remains unified. Once you hear that it becomes dispelled, you know the correct range.
As to the toe in, all the speakers I have seen, sound better without any toe in. The sound gets mixed and undefined with a more or less notable toe-in.
All three pair of Thiel speaker I have (nothing to say about the sub), sound equally good from any point, whether you are in the ideal triangle position, or at an edge. I even sometimes enjoy hearing the music from the back of the speakers.
I think a pair of descent speakers should posses similar properties.