One tweak that I have found to be very worthwhile with my 750D has been the Ammonite Acoustics mounting collar, which eliminates the slight slop in the OEM collar and ensures correct positioning of the arm as it relates to azimuth. Very important with more exotic stylus profiles.I have to second the Ammonite Accoustics mounting collar. The brilliant thing about these is that he makes them from ebony! Expensive? maybe, but not in "Hi-Fi" terms. The great thing about ebony is that it is used to make musical instruments, oboes, clarinets for example. All materials have a resonance, but the resonance of ebony is benign. Match that with a Yamamoto Ebony (or Mpingo) headshell and you will get a real benefit. Also there is the 'Shuggie Collar' as a tweak to the Jelco. They are sold by ammonite accoustics. The only downside to the Jelco is that the grub screw on the mounting collar is not centered. A bit like rolling a log but pushing it with your foot at one end instead of the centre - it might go off course. So great care is required in set up. The aftermarket collar is is essential in mounting the arm to a Technics and I guess the same can be said for a Garrard. The last tweak is silver rewiring. I am not really a 'cable guy' but I do believe the smaller the signal the more important it is to have good a good cable.
I also recently changed out the stock Jelco headshell to a Yamamoto HS4 Carbon Fiber headshell. This was a real eye (or ear) opener: pretty substantial improvements across the board in information retreival, overall presentation and dynamics. A no brainer for about $100 U.S. on ebay.
As you may have guessed I am a Jelco owner. If I was building another TT I would not go for a VPI or 'modern' tonearm. I might even plonk another Jelco on it. My other thought would be an SME M2-12.