Can upgraded power cords help my setup?

No.....I would upgrade your speaker wire...

Upgrade my speaker wire??? Ugh. Do you understand my application?

I think moebuster nailed it. I appreciate everyone’s input and I’m going to try some inexpensive power cords (Pangea or Signal Cable). I like the fact that my Class D amps would be fine going with an upgraded 14awg.  That will save a bit.  My setup isn’t that complex. It’s the two wireless speakers and a Node 2. I have been Googling and searching for others that have attempted this and haven’t found any helpful info. I got a good deal on the KEFs and the Node 2 so I’m only looking to put about $250ish max in cords if I can see a benefit over the supplied cords.

Now, I just need to figure out do I go optical digital or analog out of the Node 2 so I can get full MQA?

Try it with some with a free trial, so you aren't out much $ if they don't work out or justify their expense.  Especially from those with a free trial AND also suggest in their advertising that power cords will change your life.

Your peace of mind to know whether it actually perceptibly helps in your particular situation is probably worth the few bucks it will cost to find out.

Either way, your real-world experience and opinion might help guide the next person.

Dave (Dlcockrum), thank you kindly. But, no, I didn’t mean to imply that upgrading the power cords on the wireless LS50s would be any less (or any more) likely to be beneficial than in other applications. I was just suggesting that the uniqueness of the design results in little if any predictability of whatever differences may result, and minimizes the relevance of reported experiences that are based on other systems and setups.

Thanks again. Best regards,
-- Al

Very true Al. Thanks.

Best to you,
Dave