I'm using the antiskate. I find it to be a slight improvement worth the effort. Seems to clean up very slight distortion and maybe a bit better dynamics. I've gone back and forth, changed settings, on/off.
Trust your ears is my advice. And if you hear no difference, don't use it because general thought is better to have less than too much.
At the end of the day, though, this is a fantastic upgrade taken as a whole. My analog has never sounded this good and I can't stand seedees anymore.