There are a few people who argue you should go uncompressed, that lossless compression, even though bit perfect, loses something in the uncompressing process, perhaps due to some codec anomaly. I know, it doesn't make any sense, but hey, this is the land of audiophiles. I've started experimenting to see if I can hear a difference.
I'm amazed at how little consensus there is on the right way to best sound from the PC though.No kidding! That's what's held me off from jumping in with both feet -- I can't get a straight answer.