Can almost anyone learn to set up a Cartridge?

I continue to look for a plug and play only because I do not know how and really have no idea what so ever on how to set up a cartridge. Is this something a novice can learn and do with the manual that is supplied with the TT or cartridge? Do I purchase set up aids of one sort or another?
I want to use a MC cartridge and it seems when ever I find something I have a interest in it has a MM mounted or no cartridge at all.
Just six months ago my wife has now allowed me to change light bulbs, so I think I am ready to take that next step and be able to mount my own cartridge.
Ok fellows, be gentle, I am not a young buck, but I am eager to learn.
Thanks,
Dave