Will a quality USB cable make a difference....

Don't agree. I went from a 35.00 USB that came with my HRT Music streamer to a more expensive WireWorld USM and found a pretty big difference. Much smoother and fuller sound. I could not beleive it my self. The Wire World StarLight is a nice cable design. YMMV

I completely agree with Ml8764ag on this. I hear differences in almost ALL cables and tweaks, and have a system capable of showing off the tiniest differences. But I can not hear any difference in my cheap Belden Gold USB cable and the much more expensive Wireworld Starlight USB cable ... Save your money.

This is between a drive and computer. Most claim no difference in this application. I would be more concerned with using a USB drive w/ a USB DAC, if indeed you are...

I've spent a small fortune on interconnects and speaker wires and do think I appreciate good cables. I agree on the DAC comment as well. I didn't try the Wire World product but did try Cardas, Kimber and Audioquest and could not hear any difference between those and what came with my Mac.

Just my two cents. I can think of a dozen better (more Pareto optimal) uses for the money just in terms of tweaks and the like.

I've noticed a significant difference to the upside with a Ridge Street Audio 9 pin firewire cable between the peripheral HD and the MacMini music server. Richer, fuller, more complete sense of the music than the stock Oyen 9 pin firewire cable (which is very good imho)... this even using full memory mode using Pure Music.

Just my experience,

:) listening,

Ed