Small Speakers For A Large Room...

You might consider Silverline SR17 Supreme. I have used it in a large room with a sub with great success. It uses the Dynaudio Esotar tweeter.

I'd also suggest the Tekton m-Lores (34" x 9" x 10"). I purchased a pair for use as surround speakers, but have been toying around with them as my main speakers in a 35' x 15' x 8' loft (4200 sq feet) and have been pleasantly surprised how easily they fill the room. Very musical, big sound, surprising bass, and they sound very good on all types of music. They are not the last word on extracting all the details of the music, so be aware of that if you are a detail freak. The are easy to drive and not fussy about placement.

Check out Wavetouch audio. Grand Teton is a small monitor (12" x 7.5" x 10") with 94 db sensitivity.

Another vote for Joseph Audio Pulsars. Nice looking speakers that I'd think have a high WAF and play big for their size, especially since you'll be running a sub with them. Also, to Audiokinesis' point, I believe they have very good dispersion characteristics.

By the way, the fact that you love your wife much more than your music tells me you're either a newlywed or sorely in need of better music. Either way, best of luck.

http://www.stereomojo.com/SHELBYKROLLReferenceStandardMonitor1.0andReferenceWooferMonitor1.0.htm/SHELBYKROLLReferenceStandardMonitor1.0andReferenceWooferMonitor1.0.htm

You can probably purchase the Nano monitors for considerably less and get fairly close to the performance of the reference models. All in all, excellent speakers